Symbol
Name
ID

Tyrobp
TYRO protein tyrosine kinase binding protein
MGI:1277211

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Acute leukemia
Disease(s) Associated with TYROBP	Acute leukemia
Nasu-Hakola disease

Mouse Phenotypes

abnormal osteoclast differentiation

increased B cell proliferation

decreased T cell proliferation

decreased uterine NK cell number

abnormal myelopoiesis

increased dendritic cell number

increased germinal center B cell number

abnormal microglial cell morphology

abnormal osteoclast morphology

increased spleen germinal center number

increased spleen germinal center size

increased IgG2a level

increased IgG3 level

impaired natural killer cell mediated cytotoxicity

increased natural killer cell mediated cytotoxicity

abnormal NK T cell physiology

abnormal osteoclast physiology

Availability

Mouse Genotype

Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv

Tyrobp^tm1Lll/Tyrobp^tm1Lll

Tyrobp^tm1Ttk/Tyrobp^tm1Ttk

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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